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Viagra is a medication used to treat erectile dysfunction. Viagra increases blood flow to the penis. It is a phosphodiesterase type 5 inhibitor, abbreviated PDE5 inhibitor. Drugs such as Viagra inhibit the effect of phosphodiesterase, an enzyme responsible for the destruction of cGMP. When cGMP (cyclic guanosine monophosphate) circulates, smooth muscles relax, and the blood vessels that supply blood to the penis dilate, facilitating erection by increasing blood flow.

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  • Viagra acts selectively to target PDE5, promoting a cascade of events. Increased delivery of nitric oxide to the cells that line blood vessels (endothelium) occurs to relax and dilate the blood vessels and improve blood flow and produce erection. Nitric oxide plays an important role in blood vessel health and blood flow throughout the body, and is especially important to facilitate blood flow to the penis.

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    The recommended dose is 25 to 50 mg taken about one hour before sexual activity. According to the "Drug Information Handbook," the medication may be taken anywhere from 30 minutes to four hours before sexual activity.

    Sildenafil is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state. When sildenafil is taken with a high fat meal, the rate of absorption is reduced, with an average delay in the time to maximal concentration of 1 hour.

    There are generally no serious side effects of Viagra, though the most common side effect is dizziness. This side effect occurs due to a change (reduction) in blood pressure. Another side effect of Viagra is an erection that lasts for 3 to 4 hours. Blurry vision, headaches, a slight stomach upset, sinus congestion, and hot flashes are other common side effects. Rare cases of chest pain and chest tightening have also been reported. These side effects suggest that the individual has some kind of underlying heart problem. Heart attacks caused by Viagra are rare, but have nevertheless been reported.





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